Modern biomedical research and preclinical pharmaceutical development rely heavily on the phenotyping of small vertebrate models for various diseases prior to human testing. In this project, we demonstrate an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging and digital reconstruction of zebrafish larvae for quantitative phenotypic analysis. (Nature communications, 2021)

Acoustic streaming has been widely used in microfluidics to manipulate various micro−/nano-objects. In this work, acoustic streaming activated by interdigital transducers (IDT) immersed in highly viscous oil is studied numerically and experimentally. (Lab on a chip, 2018, Nature communications, 2018, Science advances, 2020)

Liquid droplets have been studied for decades and have recently experienced renewed attention as a simplified model for numerous fascinating physical phenomena occurring on size scales from the cell nucleus to stellar black holes. Here, we present an acoustofluidic centrifugation technique that leverages an entanglement of acoustic wave actuation and the spin of a fluidic droplet to enable nanoparticle enrichment and separation.  (Science advances, 2021)

Acoustic-based techniques can manipulate particles in a label-free, contact-free, and biocompatible manner. Acoustic holography is an emerging technique that offers the potential to generate arbitrary pressure distributions which can be applied to particle manipulation with higher degrees of freedom. Here, we introduce a holography technique that leverages both an arbitrary acoustic field and controllable fluid motion to offer an effective approach for manipulating micro/nano particles. (ACS nano, 2020)